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【题目】Whole Genome Resequencing Reveals Selection Signatures Associated With Important Traits in Ethiopian Indigenous Goat Populations
【作者】马月辉
【摘要】
  Ethiopia is considered as the main gateway for the introduction of livestock species,including goat, to the African continent.Ethiopian goats are characterized by their unique adaptive ability,and different physical characteristics in terms of morphology,body size,coat colors, and other important traits.The comparative population genomic analysis provides useful genomic information associated with important traits. Whole-genome resequencing of 44 Ethiopian indigenous goats produced 16 million single-nucleotide polymorphisms (SNPs) as well as 123,577 insertions and deletions.Specifically,11,137,576,10,760,581,10,833,847, 12,229,657 and 10,749,996 putative SNPs were detected in Abergelle,Afar,Begait,Central Highland and Meafure goat populations,respectively.In this study,we used population differentiation (FST) and pooled heterozygosity (HP) Cbased approaches.From the FST analysis, we identified 480 outlier windows.The HP approach detected 108 and 205 outlier windows for Abergelle,and Begait,respectively. About 11 and 5 genes under selective signals were common for both approaches that were associated with important traits.After genome annotation,we found 41 Gene ontology (GO) terms (12 in biological processes,8 in cellular components and 11 in the molecular function) and 10 Kyoto Encyclopedia of Genes and Genomes pathways.Several of the candidate genes are involved in the reproduction,body weight,fatty acids,and disease related traits.Our investigation contributes to deliver valuable genetic information and paves the way to design conservation strategy,breed management,genetic improvement,and utilization programs.The genomic resources generated in the study will offer an opportunity for further investigations.
【关键词】candidate genes,Capra hircus,pooled heterozygosity,population differentiation,positive selection signature
【日期】2019-12-28
【资料来源】frontiers in genetics
【全文浏览】全文浏览



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